Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ CA-074
CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ GR 127935 Hydrochloride
A selective 5-HT1B/1D receptor antagon
MilliporeSigma™ Calbiochem™ Chelerythrine Chloride
Naturally-occurring alkaloid.
MilliporeSigma™ Calbiochem™ γ-Secretase Inhibitor XXI, Compound E
This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch processing. Lowers Aβ levels in APP transgenic mice.
MilliporeSigma™ Calbiochem™ eEF2K Inhibitor, A-484954
The eEF2K Inhibitor, A-484954, also referenced under CAS 142557-61-7, controls the biological activity of eEF2K Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Okadaic Acid, Potassium Salt
Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
MilliporeSigma™ Calbiochem™ Tetrabenazine, TBZ
A monoamine-depleting agent that blocks vesicular monoamine transporter 2 activity. Promotes late-stage differentiation of Pdx1 + pancreatic progenitor cells into Ngn3 + endocrine precursors.
MilliporeSigma™ Calbiochem™ GSK-3 Inhibitor IX, Control, MeBIO
The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Foxo1 Inhibitor, AS1842856
Foxo1 Inhibitor, AS1842856, is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 (IC50 = 33 nM). Directly binds to the active Foxo1, but not the Ser256-phosphorylated form.
MilliporeSigma™ Calbiochem™ Etoposide
Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2μM). Displays anti-tumor activity.
MilliporeSigma™ Calbiochem™ NG,NG'-Dimethyl-L-arginine, Dihydrochloride
Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.
MilliporeSigma™ Calbiochem™ HIF Prolyl Hydroxylase Inhibitor
A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2μM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to lucifer
MilliporeSigma™ Calbiochem™ Oridonin, R. rubescens
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.
MilliporeSigma™ Calbiochem™ p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5
The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ PAR-2 Agonist I
The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.